Synthesis, characterization, and antibacterial activity of 6-Chloro-8-methyl-2-oxo-2H-chromene-3-carboxylic acid ethyl ester
Latha Rani, N; Prashanth, T; Sridhar, MA; Gurupadaswamy, HD; Shaukath Ara, K; Lokanath, NK
| HERO ID | 4933338 |
|---|---|
| In Press | No |
| Year | 2016 |
| Title | Synthesis, characterization, and antibacterial activity of 6-Chloro-8-methyl-2-oxo-2H-chromene-3-carboxylic acid ethyl ester |
| Authors | Latha Rani, N; Prashanth, T; Sridhar, MA; Gurupadaswamy, HD; Shaukath Ara, K; Lokanath, NK |
| Journal | Molecular Crystals and Liquid Crystals |
| Volume | 624 |
| Issue | 1 (January 2 |
| Page Numbers | 262-270 |
| Abstract | The title compound was synthesized by reacting 2-hydroxy-4-methoxy-benzaldehyde with diethyl malonate in the presence of piperidine catalyst and ethanol as solvent. The chemical structure of the title compound was elucidated by elemental analysis, super(1)H-NMR, and IR. The crystal structure was determined by X-ray diffraction data. It crystallizes in monoclinic crystal system, P2 sub(1)/c space group with unit cell parameters, a = 12.840(2) Aa, b = 24.790(4) Aa, c = 7.8544(13) Aa, beta = 98.035(5) degree , V = 2475.5(7) Aa super(3), and Z = 8. The molecular and crystal structure of the title compound is stabilized by inter- and intramolecular interactions of the type C-H...O. The newly synthesized compound was screened for its antibacterial activity against two gram-positive and two gram-negative bacteria. |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Keyword | Data processing; Piperidine; Antibacterial activity; Gram-negative bacteria; Solvents; Crystal structure; Catalysts; Crystals; X-ray diffraction; Esters; Ethanol; 2016) |