SYNTHESIS AND ANTIMICROBIAL EVALUATION OF 4-BENZYLIDENE- PYRAZOLIDINE-3, 5-DIONE DERIVATIVES
Kumar, H; Jain, S
| HERO ID | 4933345 |
|---|---|
| Year | 2013 |
| Title | SYNTHESIS AND ANTIMICROBIAL EVALUATION OF 4-BENZYLIDENE- PYRAZOLIDINE-3, 5-DIONE DERIVATIVES |
| Authors | Kumar, H; Jain, S |
| Publisher Text | International Journal of Pharmaceutical Sciences and Drug Research |
| Volume | 4 |
| Page Numbers | 453. |
| Abstract | In the present research work, diethyl malonate and phenyl hydrazine were reacted together to give pyrazolidine-3,5-dione nucleus which was further derivatized at fourth position by reacting with different aromatic aldehydes to give 4-benzylidene-pyrazolidine-3,5-diones, followed by the 4-chloro-butyl and 4-nitrooxy-butyl substitution at nitrogen atom. The synthesized products were characterized by physicochemical and analytical means. Few of the synthesized derivatives showed excellent antibacterial and antifungal activities. |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal:International Journal of Pharmaceutical Sciences and Drug Research ISSN:0975-8232 |
| Is Public | Yes |
| Keyword | Antifungal activity; Aldehydes |