Studies on antitumor substances. XII. Synthesis of bis(2,3-epoxypropyl)amine derivatives and the reaction with some nucleophiles
Hayashi, S; Furukawa, M; Fujino, Y; Sugita, M; Nakao, T
| HERO ID | 4933528 |
|---|---|
| In Press | No |
| Year | 1971 |
| Title | Studies on antitumor substances. XII. Synthesis of bis(2,3-epoxypropyl)amine derivatives and the reaction with some nucleophiles |
| Authors | Hayashi, S; Furukawa, M; Fujino, Y; Sugita, M; Nakao, T |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 19 |
| Issue | 10 |
| Page Numbers | 2003-2008 |
| Abstract | Several bis (2, 3-epoxypropyl) amine derivatives were successfully synthesized by the modification of Homer's method. N, N'-Bis (2, 3-epoxypropyl) piperazine and p-bis (2, 3-epoxypropoxy) benzene were attempted to react with thiols, amines and phenol, and the corresponding ring opening compounds of the epoxide ring were obtained in good yields, respectively. N, N'-Bis (2, 3-epoxypropyl) piperazine and p-bis (2, 3-epoxypropoxy) benzene also reacted with diethyl malonate to give N, N'-bis (?-ethoxycarbonyl-?-butyrolacton-a-yl) methyl piperazine and p-bis (?-ethoxycarbonyl-?-butyrolacton-a-yl) methoxy benzene, respectively. © 1971, The Pharmaceutical Society of Japan. All rights reserved. |
| Doi | 10.1248/cpb.19.2003 |
| Pmid | 5137272 |
| Url | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0015137362&doi=10.1248%2fcpb.19.2003&partnerID=40&md5=db13db70320ed58452d042cc4e231435 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |