Synthesis of Potential Anticancer Agents. IV. 5, 7-Disubstituted s-Triazolo [2, 3-a] pyrimidines
Makisumi, Y
| HERO ID | 4933565 |
|---|---|
| In Press | No |
| Year | 1961 |
| Title | Synthesis of Potential Anticancer Agents. IV. 5, 7-Disubstituted s-Triazolo [2, 3-a] pyrimidines |
| Authors | Makisumi, Y |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 9 |
| Issue | 10 (1961) |
| Page Numbers | 801 |
| Abstract | The products of the condensation of 5-amino-s-triazole (I) with ethyl malonate, ethyl cyanoacetate, and methyl ethoxycarbonyldithioacetate were proved to be respectively 5, 7-dihydroxy-, 5-hydroxy-7-amino-, and 5-hydroxy-7-mercapto-s-triazolo [2, 3-a] pyriminines (II, III, and IV). (II) was converted into the 5, 7-dichloro derivative (VI), and the reactivity of the two halogens in (VI) towards the usual nucleophilic reagents was examined. (IV) was also transformed into the 5-chloro-7-methylthio derivative (XXI), which was converted into 5-substituted 7-methylthio derivatives by nucleophilic substitution. Ultraviolet absorption spectra of 5-substituted and 7-substituted s-triazolo [2, 3-a] pyrimidines were compared. |
| Doi | 10.1248/cpb.9.801 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Is Peer Review | Yes |
| Relationship(s) |
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