Studies on Antitumor Substances. XIV. Syntheses of Bisquarternary Ammonium Salts and the Reaction with Nucleophiles
Hayashi, S; Furukawa, M; Fujino, Y; Ishii, N; Kamijo, Y
| HERO ID | 4933578 |
|---|---|
| In Press | No |
| Year | 1972 |
| Title | Studies on Antitumor Substances. XIV. Syntheses of Bisquarternary Ammonium Salts and the Reaction with Nucleophiles |
| Authors | Hayashi, S; Furukawa, M; Fujino, Y; Ishii, N; Kamijo, Y |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 20 |
| Issue | 1 (1972) |
| Page Numbers | 15 |
| Abstract | Several bisquarternary ammonium salts were synthesized and tested as to their antitumor activity. However, none of them exhibited any effective activity. Additionally, alkylation of nucleophiles with quarternary ammonium salts, dimethylaminomethyl p-tolyl ether methiodide and ethylene bis (N, N-diethyl-N-methylammonium iodide), was examined. Dimethylaminomethyl p-tolyl ether methiodide reacted successfully with nucleophiles, such as amine, thiol and alcohol, to give the expected compounds in which p-tolyloxymethyl group was introduced to the nucleophilic compounds. On the other hand, ethylene his (N, N-diethyl-N-methylammonium iodide) reacted with thiophenol and diethyl malonate to give the methylated compounds, methyl phenyl sulfide and diethyl malonate respectively. |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
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