Synthesis of arphamenine A and epi-arphamenine A
Umezawa, H; Nakamura, T; Fukatsu, S; Agyagi, T; Tatsuta, K
| HERO ID | 4933588 |
|---|---|
| In Press | No |
| Year | 1983 |
| Title | Synthesis of arphamenine A and epi-arphamenine A |
| Authors | Umezawa, H; Nakamura, T; Fukatsu, S; Agyagi, T; Tatsuta, K |
| Journal | Journal of Antibiotics |
| Volume | 36 |
| Issue | 12 (1983) |
| Page Numbers | 1787-1788 |
| Abstract | Arphamenine A, produced from Chromobacterium violaceum BMG361-CF4 as an amino peptidase B inhibitor, is the first naturally occurring carba analog of peptide and epi-arphamenine A is the artifact from the epimerization at C-2. Here the authors describe the synthesis of optically active arphamenine A and epi-arphamenine A. Since in these compounds epimerization at C-2 should be inevitable, the C-1 similar to C-3 portion was synthesized by "malonic ester synthesis" which gave the diastereomers. |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Keyword | Chromobacterium violaceum |