Synthesis and anti-TMV activity of dialkyl/dibenzyl 2-((6-substituted-benzo[d]thiazol-2-ylamino)(benzofuran-2-yl)methyl) malonates
Xiao, H; Zheng, P; Tang, C; Xie, Y; Wu, F; Song, J; Zhao, J; Li, Z; Li, M
| HERO ID | 4933597 |
|---|---|
| In Press | No |
| Year | 2013 |
| Title | Synthesis and anti-TMV activity of dialkyl/dibenzyl 2-((6-substituted-benzo[d]thiazol-2-ylamino)(benzofuran-2-yl)methyl) malonates |
| Authors | Xiao, H; Zheng, P; Tang, C; Xie, Y; Wu, F; Song, J; Zhao, J; Li, Z; Li, M |
| Journal | Molecules |
| Volume | 18 |
| Issue | 11 |
| Page Numbers | 13623-13635 |
| Abstract | Starting from benzofuran-2-methanal, 6-substituted benzothiazole-2-amines and malonic esters, sixteen title compounds were designed and synthesized seeking to introduce anti-TMV activity. The structures of the newly synthesized compounds were confirmed by 1H-NMR, 13C-NMR, IR spectra, and MS (HREI) analysis. The bioassays identified some of these new compounds as having moderate to good anti-TMV activity. The compounds 5i and 5m have good antiviral activity against TMV with a curative rate of 52.23% and 54.41%, respectively, at a concentration of 0.5 mg/mL. |
| Doi | 10.3390/molecules181113623 |
| Pmid | 24192914 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |