Synthesis of Novel Pyrido[1,2-a]pyrimidine-3-carboxamide Derivatives and Their Anticancer Activity
Santhosh Kumar, G; Jitender Dev, G; Ravi Kumar, N; Krishna Swaroop, D; Poorna Chandra, Y; Ganesh Kumar, C; Narsaiah, B
| HERO ID | 4933598 |
|---|---|
| In Press | No |
| Year | 2015 |
| Title | Synthesis of Novel Pyrido[1,2-a]pyrimidine-3-carboxamide Derivatives and Their Anticancer Activity |
| Authors | Santhosh Kumar, G; Jitender Dev, G; Ravi Kumar, N; Krishna Swaroop, D; Poorna Chandra, Y; Ganesh Kumar, C; Narsaiah, B |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 63 |
| Issue | 8 |
| Page Numbers | 584-590 |
| Abstract | A series of novel pyrido[1,2-a]pyrimidine-3-carboxamide derivatives 6a-n were prepared starting from 2(1H) pyridone 1 via hydrolysis, de-carboxylation, selective O-alkylation followed by rearrangement to give pyridine-2-amine 3. Compound 3 on reaction with ethoxy methylene malonic diethyl ester (EMME) under a conventional method followed by cyclization under micro wave irradiation (MWI) conditions resulted in product 5. Compound 5 on coupling with diverse substituted aliphatic amines formed title compounds 6a-n. All the products 6a-n were screened against four human cancer cell lines and compounds 6h-k and n which showed promising anticancer activity have been identified. |
| Doi | 10.1248/cpb.c15-00219 |
| Pmid | 26235166 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |