SELECTIVE SYNTHESIS OF TRANS-ANTI-CIS (TAC) OR CIS-ANTI-TRANS (CAT) TRICYCLES FROM THE TRANSANNULAR DIELS-ALDER OF TTT MACROCYCLIC TRIENES

Soucy, P; Dory, YL; Deslongchamps, P

HERO ID

4935908

Reference Type

Journal Article

Year

1994

HERO ID 4935908
In Press No
Year 1994
Title SELECTIVE SYNTHESIS OF TRANS-ANTI-CIS (TAC) OR CIS-ANTI-TRANS (CAT) TRICYCLES FROM THE TRANSANNULAR DIELS-ALDER OF TTT MACROCYCLIC TRIENES
Authors Soucy, P; Dory, YL; Deslongchamps, P
Journal Bulletin de la Société Chimique de Paris
Volume 131
Issue 3
Page Numbers 271-278
Abstract The synthesis and transannular Diels-Alder reactions of trans-trans-trans (TTT) macrocyclic trienes 16 and 26 containing a dimethyl malonate and a monomethyl ester are reported. Compound 16 yields a mixture of two trans-anti-cis (TAC), (27, 73% and 28, 19%) and one cis-anti-trans (CAT) tricycle (29, 8%). Macrocycle 26 gives one TAC (31, 17%) and two CAT tricycles (33, 78% and 34, 5%). These results are explained by considering steric effects in competing chair-boat-chair and chair-boat-boat transition states.
Wosid WOS:A1994NF80600004
Is Certified Translation No
Dupe Override No
Is Public Yes
Keyword STEREOCONTROLLED SYNTHESIS; MACROCYCLES; TRICYCLES; TRANSANNULAR DIELS-ALDER REACTION; CYCLOADDITION