Synthesis of pyrido[2 ',3 ': 3,4]pyrazolo[5,1-c] triazine, pyrazolo[3,4-b]pyridin-3-ylphenylthiourea derivatives and their biological evaluation
Attaby, FA; Elghandour, AH; Ali, MA; Ibrahem, YM
| HERO ID | 4936114 |
|---|---|
| In Press | No |
| Year | 2006 |
| Title | Synthesis of pyrido[2 ',3 ': 3,4]pyrazolo[5,1-c] triazine, pyrazolo[3,4-b]pyridin-3-ylphenylthiourea derivatives and their biological evaluation |
| Authors | Attaby, FA; Elghandour, AH; Ali, MA; Ibrahem, YM |
| Journal | Afinidad |
| Volume | 63 |
| Issue | 525 |
| Page Numbers | 417-425 |
| Abstract | Pyrazolo[3,4-b]pyridine-5-carbonitrile derivative 1 was diazotized to give the corresponding diazonium salt 2 which was used as a good synthon to synthesize pyrido[2',3':3,4]pyrazolo[5,1-c]triazines 5, 8, 15a-c and 19 via its coupling with several active-hydrogen containing reagents e.g. 2,4-pentanedione, ethyl 3-oxobutanoate, diethyl malonate, malononitrile, 2-cyanoethanethioamide and ethyl cyanoacetate. Also, it reacts with phenyl isothiocyanate to afford the corresponding pyrazolo[3,4b]pyridin-3-yiphenylthiourea derivative 20 which in turn, used for further chemical transformations to afford com- pounds 25a,b, 29, 31 and 32. Considering the data of IR, H-1 NMR, mass spectra and chemical analyses the structures of all newly synthesized heterocyclic compounds were elucidated. Cytotoxicity, anti HSV1 and anti HAV, MBB activities were evaluated for all newly synthesized heterocyclic compounds. |
| Wosid | WOS:000246285000011 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Keyword | 2-cyanoethanethioamide; pyridine-5-carbonitrile; phenyl isothiocyanate; pyridopyrazolotriazines; pyrazolopyridin-3-ylphenylthiourea |