Preparation of indole-phosphine oxazoline (IndPHOX) ligands and their application in allylic alkylation
Wang, Yu; Hamalainen, A; Tois, Jan; Franzen, R
| HERO ID | 4936170 |
|---|---|
| In Press | No |
| Year | 2010 |
| Title | Preparation of indole-phosphine oxazoline (IndPHOX) ligands and their application in allylic alkylation |
| Authors | Wang, Yu; Hamalainen, A; Tois, Jan; Franzen, R |
| Journal | Tetrahedron: Asymmetry |
| Volume | 21 |
| Issue | 19 |
| Page Numbers | 2376-2384 |
| Abstract | Two classes of indole-phosphine oxazoline ligands have been prepared from readily available starting materials in good overall yields. These modular ligands include an indole skeleton with either a phosphine moiety or an oxazoline ring at the 2- or 3-position, respectively. The utility of these ligands was demonstrated in a catalytic asymmetric reaction: the palladium-catalyzed allylic alkylation of 1,3-diphenyl-2-propenyl acetate with dimethyl malonate was performed with enantioselectivities as high as 98%. (C) 2010 Elsevier Ltd. All rights reserved. |
| Doi | 10.1016/j.tetasy.2010.08.008 |
| Wosid | WOS:000284728400010 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |