The toxicity of behenyl alcohol. I. Genotoxicity and subchronic toxicity - Genetic Toxicity in vitro, (661-19-8) 1-Docosanol
Iglesias, G; Hlywka, JJ; Berg, JE; Khalil, MH; Pope, LE; Tamarkin, D
HERO ID
4941014
Reference Type
Technical Report
Year
2002
Language
English
| HERO ID | 4941014 |
|---|---|
| Year | 2002 |
| Title | The toxicity of behenyl alcohol. I. Genotoxicity and subchronic toxicity - Genetic Toxicity in vitro, (661-19-8) 1-Docosanol |
| Authors | Iglesias, G; Hlywka, JJ; Berg, JE; Khalil, MH; Pope, LE; Tamarkin, D |
| Publisher Text | U.S. Environmental Protection Agency :: U.S. EPA |
| Abstract | Both assays demonstrated a lack of mutagenic activity by behenyl alcohol. No significant and reproducible increases in the number of revertants were found in any strain and behenyl alcohol treatment group combination relative to the solvent control. In addition, no concentration-dependent enhancement of the revertant number occurred, and no differences were observed between behenyl alcohol treatments with or without metabolic activation. Strain text description: S. typhimurium strains TA1535, TA1537, TA1538, TA98, and TA100 Criteria for Postive Results: For a test substance to be considered positive in tester strain TA100, at least a twofold increase was required in the number of reversions. In tester strains TA1535, TA1537, TA1538, and TA98, a test substance was considered positive when the number of reversions was at least three times higher than the spontaneous reversion rate. In addition, a dose-dependent increase in the number of revertants was regarded as an indication of possible mutagenic potential, regardless of whether the highest dose induced a two- to threefold increase in the number of revertants. Genotoxic Effect: Negative |
| Url | https://ofmpub.epa.gov/oppthpv/Public_Search.PublicEndPointReport?robust_summary_id=24960394&WhichButton=PrintTab&ep_name=Genetic+Toxicity+in+vitro&selchemid= |
| Is Certified Translation | No |
| Dupe Override | No |
| Number Of Pages | 2 |
| Is Public | Yes |
| Language Text | English |