Bioprocess scale-up/down as integrative enabling technology: from fluid mechanics to systems biology and beyond
Delvigne, F; Takors, R; Mudde, R; van Gulik, W; Noorman, H
| HERO ID | 4943343 |
|---|---|
| In Press | No |
| Year | 2017 |
| Title | Bioprocess scale-up/down as integrative enabling technology: from fluid mechanics to systems biology and beyond |
| Authors | Delvigne, F; Takors, R; Mudde, R; van Gulik, W; Noorman, H |
| Journal | Microbial Biotechnology |
| Volume | 10 |
| Issue | 5 |
| Page Numbers | 1267-1274 |
| Abstract | Efficient optimization of microbial processes is a critical issue for achieving a number of sustainable development goals, considering the impact of microbial biotechnology in agrofood, environment, biopharmaceutical and chemical industries. Many of these applications require scale-up after proof of concept. However, the behaviour of microbial systems remains unpredictable (at least partially) when shifting from laboratory-scale to industrial conditions. The need for robust microbial systems is thus highly needed in this context, as well as a better understanding of the interactions between fluid mechanics and cell physiology. For that purpose, a full scale-up/down computational framework is already available. This framework links computational fluid dynamics (CFD), metabolic flux analysis and agent-based modelling (ABM) for a better understanding of the cell lifelines in a heterogeneous environment. Ultimately, this framework can be used for the design of scale-down simulators and/or metabolically engineered cells able to cope with environmental fluctuations typically found in large-scale bioreactors. However, this framework still needs some refinements, such as a better integration of gas-liquid flows in CFD, and taking into account intrinsic biological noise in ABM. |
| Doi | 10.1111/1751-7915.12803 |
| Pmid | 28805306 |
| Wosid | WOS:000411491300055 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |