Synthesis and Biological Evaluation of Thiophene-C-glucosides as Sodium-Dependent Glucose Cotransporter 2 Inhibitors
Sakamaki, S; Kawanishi, E; Koga, Y; Yamamoto, Y; Kuriyama, C; Matsushita, Y; Ueta, K; Nomura, S
| HERO ID | 4947098 |
|---|---|
| In Press | No |
| Year | 2013 |
| Title | Synthesis and Biological Evaluation of Thiophene-C-glucosides as Sodium-Dependent Glucose Cotransporter 2 Inhibitors |
| Authors | Sakamaki, S; Kawanishi, E; Koga, Y; Yamamoto, Y; Kuriyama, C; Matsushita, Y; Ueta, K; Nomura, S |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 61 |
| Issue | 10 |
| Page Numbers | 1037-1043 |
| Abstract | The synthesis and structure-activity relationship (SAR) of thiophene-C-glucosides have been explored, and the human sodium-dependent glucose cotransporter 2 (hSGLT2) inhibitory activities and rat urinary glucose excretion (UGE) effects of 3a-f were evaluated. As a result, they showed good hSGLT2 inhibitory activities and rat UGE effects. In particular, the chlorothiophene derivative 3f showed remarkable inhibitory activity against hSGLT2. |
| Doi | 10.1248/cpb.c13-00407 |
| Wosid | WOS:000326302300008 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Keyword | sodium-dependent glucose cotransporter; glucal-boronate; thiophene-C-glucoside |