Octadecan-1-ol: developmental toxicity/teratogenicity: 001 key | experimental result
HERO ID
4962975
Reference Type
Technical Report
Year
1992
Language
English
| HERO ID | 4962975 |
|---|---|
| Year | 1992 |
| Title | Octadecan-1-ol: developmental toxicity/teratogenicity: 001 key | experimental result |
| Authoring Organization | European Chemicals Agency |
| Publisher Text | ECHA |
| City | Helsinki, Finland |
| Abstract | Conclusions: In a reliable study, development was assessed as part of a combined repeat dose and reproductive/developmental toxicity study, conducted according to draft OECD guideline 422. The NOAEL for maternal and foetotoxicity in rats was 2000 mg/kg bw/day (highest dose level). There was no evidence of teratogenicity from the limited examination of the pups that was carried out. The result is read across from octadecan-1-ol (CAS 112-92-5). Executive summary: Based on the weight of evidence from other alcohols across the category and the combined repeat dose/reproductive/developmental study with octadecan-1-ol, it is concluded that octadecan-1-ol is unlikely to be a developmental toxicant in the absence of maternal toxicity. |
| Url | https://echa.europa.eu/registration-dossier/-/registered-dossier/15937/7/9/3 |
| Is Certified Translation | No |
| Dupe Override | No |
| Number Of Pages | 5 |
| Is Public | Yes |
| Language Text | English |