Lead-induced hypertension: Possible role of endothelial factors
Khalil-Manesh, F; Gonick, HC; Weiler, EWJ; Prins, B; Weber, MA; Purdy, RE
HERO ID
59080
Reference Type
Journal Article
Year
1993
Language
English
PMID
| HERO ID | 59080 |
|---|---|
| In Press | No |
| Year | 1993 |
| Title | Lead-induced hypertension: Possible role of endothelial factors |
| Authors | Khalil-Manesh, F; Gonick, HC; Weiler, EWJ; Prins, B; Weber, MA; Purdy, RE |
| Journal | American Journal of Hypertension |
| Volume | 6 |
| Issue | 9 |
| Page Numbers | 723-729 |
| Abstract | The results of this study confirm that low lead (0.01%) but not high lead (0.5%) administration results in increased blood pressure in rats treated for up to 12 months. This effect appeared to be related to an imbalance of endothelially-derived vasoconstrictor and vasodilator compounds in low lead-treated animals but not in high lead-treated animals. In low lead-treated rats, measurement of plasma endothelins 1 and 3 (ET-1 and ET-3) revealed that ET-3 concentration increased significantly after both 3 months (Experimental, 92.1 +/- 9.7 v Control, 46.7 +/- 12.0 pmol/mL; P < .001) and 12 months (Experimental, 105.0 +/- 9.3 v Control, 94.1 +/- 5.0 pmol/mL; P < .01) while ET-1 was unaffected. Plasma and urinary cGMP concentrations (as a reflection of endothelium-derived relaxing factor (EDRF)) decreased significantly at 3 months (plasma, Experimental, 1.8 +/- 0.9 v Control, 4.2 +/- 1.6 pmol/mL; P < .001) and 12 months (plasma, Experimental, 2.2 +/- 0.7 v Control, 4.2 +/- 0.9 pmol/mL; P < .001). Thus, the path to development of hypertension in low lead rats may be through an increase in the concentration of the vasoconstrictor hormone, ET-3, and a decrease in the vasodilator hormone, EDRF. High levels of lead exposure did not result in hypertension, perhaps because plasma concentrations of ET-1, ET-3 and cGMP were unaltered at 3 months, while ET-1, ET-3 and cGMP concentrations were coordinately and significantly decreased at 12 months. |
| Doi | 10.1093/ajh/6.9.723 |
| Pmid | 8110424 |
| Wosid | WOS:A1993LX41800001 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |