1.06: Dermal exposure and absorption of chemicals
Kissel, JC; Bunge, AL; Frasch, HF; Kasting, GB
HERO ID
5926055
Reference Type
Book/Book Chapter
Year
2018
Language
English
| HERO ID | 5926055 |
|---|---|
| Year | 2018 |
| Title | 1.06: Dermal exposure and absorption of chemicals |
| Book Title | Comprehensive Toxicology |
| Authors | Kissel, JC; Bunge, AL; Frasch, HF; Kasting, GB |
| Editor | McQueen, CA |
| Publisher Text | Elsevier Science |
| City | Oxford, UK |
| Volume | 1 |
| Page Numbers | 112-127 |
| Abstract | Human skin behaves as a semipermeable membrane, permitting uptake of chemicals from the external environment. Negative consequences of dermal exposure to chemicals are well documented and include both local and systemic effects. Evaluation and management of potential toxicity and risk associated with dermal exposure requires prediction of the rate and extent of chemical absorption. Historically, both experimental and mathematical approaches have been applied to the investigation of absorption processes. This chapter reviews factors influencing the outcome of absorption experiments and describes rudimentary characteristics of mathematical models. It is intended to provide useful perspective to persons responsible for conducting, interpreting, or implementing occupational or environmental health risk assessments that involve dermal exposure. |
| Doi | 10.1016/B978-0-12-801238-3.64264-2 |
| Is Certified Translation | No |
| Dupe Override | No |
| Isbn | 9780081006016 |
| Edition | 3rd |
| Is Public | Yes |
| Language Text | English |