Airway fibrosis in rats induced by vanadium pentoxide
Bonner, JC; Rice, AB; Moomaw, CR; Morgan, DL
HERO ID
595435
Reference Type
Journal Article
Year
2000
Language
English
PMID
| HERO ID | 595435 |
|---|---|
| In Press | No |
| Year | 2000 |
| Title | Airway fibrosis in rats induced by vanadium pentoxide |
| Authors | Bonner, JC; Rice, AB; Moomaw, CR; Morgan, DL |
| Journal | American Journal of Physiology: Lung Cellular and Molecular Physiology |
| Volume | 278 |
| Issue | 1 |
| Page Numbers | L209-L216 |
| Abstract | Vanadium pentoxide (V(2)O(5)) is a cause of occupational asthma and bronchitis. We previously reported that intratracheal instillation of rats with V(2)O(5) causes fibrosis of the lung parenchyma (J. C. Bonner, P. M. Lindroos, A. B. Rice, C. R. Moomaw, and D. L. Morgan. Am. J. Physiol. Lung Cell. Mol. Physiol. 274: L72-L80, 1998). In this report, we show that intratracheal instillation of V(2)O(5) induces airway remodeling similar to that observed in individuals with asthma. These changes include airway smooth muscle cell thickening, mucous cell metaplasia, and airway fibrosis. The transient appearance of peribronchiolar myofibroblasts, which were desmin and vimentin positive, coincided with a twofold increase in the thickness of the airway smooth muscle layer at day 6 after instillation and preceded the development of airway fibrosis by day 15. The number of nuclear profiles within the smooth muscle layer also increased twofold after V(2)O(5) instillation, suggesting that hyperplasia accounted for thickening of the smooth muscle layer. The majority of cells incorporating bromodeoxyuridine at day 3 were located in the connective tissue surrounding the airway smooth muscle wall that was positive for vimentin and desmin. These data suggest that myofibroblasts are the principal proliferating cell type that contributes to the progression of airway fibrosis after V(2)O(5) injury. |
| Pmid | 10645909 |
| Wosid | WOS:000084838000027 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000084838000027 |
| Is Public | Yes |
| Language Text | English |
| Keyword | asthma; myofibroblasts; smooth muscle cell; collagen; metals |
| Is Qa | No |