[A study on developmental toxicity of vanadium pentoxide in NIH mice]
Zhang, T; Gou, X; Yang, Z
HERO ID
597093
Reference Type
Journal Article
Year
1991
Language
Chinese
PMID
| HERO ID | 597093 |
|---|---|
| In Press | No |
| Year | 1991 |
| Title | [A study on developmental toxicity of vanadium pentoxide in NIH mice] |
| Authors | Zhang, T; Gou, X; Yang, Z |
| Journal | Huaxi Yike Daxue Xuebao / Journal of West China University of Medical Sciences |
| Volume | 22 |
| Issue | 2 |
| Page Numbers | 192-195 |
| Abstract | There is no general agreement yet about the teratogenic effects or developmental toxicity of vanadium in animal studies. This is a report on developmental toxicity in NIH mice following injection of vanadium pentoxide (V2O5, 5 mg/kg body weight, i.p.) at different times of gestation (on days 1-5, 6-15, 7, 8, 9, 10, 11, 14-17 of gestation). No adverse effects of V2O5 on pre-implantation and implantation were noted, and neither were teratogenicity and premature birth. However, there was toxic effect on embryofetus. Increased frequency of resorption or fetal death on days 6-15, 7, 14-17 of gestation were observed. Delayed ossification of bones was noted on days 6-15, 8, 10, 14-17 of gestation. These results suggest that V2O5 may be a weak developmental toxicant but not a teratogen in NIH mice. In addition, this paper reports the developmental toxicity, especially teratogenicity of N, N'-methylene-bis (2-amino-1, 3, 4-thiadiazole) which was used as the positive control in NIH mice. |
| Pmid | 1786959 |
| Wosid | BCI:BCI199192026590 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | Chinese |
| Relationship(s) |
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