Cytogenetic analysis of human peripheral blood lymphocytes in culture exposed in vitro to styrene and styrene oxide
Pohlová, H; Rössner, P; Srám, RJ
HERO ID
597935
Reference Type
Journal Article
Year
1984
Language
English
PMID
| HERO ID | 597935 |
|---|---|
| In Press | No |
| Year | 1984 |
| Title | Cytogenetic analysis of human peripheral blood lymphocytes in culture exposed in vitro to styrene and styrene oxide |
| Authors | Pohlová, H; Rössner, P; Srám, RJ |
| Journal | Journal of Hygiene, Epidemiology, Microbiology and Immunology |
| Volume | 29 |
| Issue | 3 |
| Page Numbers | 269-274 |
| Abstract | Styrene and styrene oxide mutagenicity was tested in cultured human lymphocytes treated in vitro with various concentrations of test agents. Styrene alone was found mutagenic at the highest concentration used (5 X 10(-4) mol. l-1, combined with the alkylating agent THIO-TEPA it did not affect the chromosome aberration yield. Exposure to styrene oxide gave a positive result showing a clear-cut dose-effect relationship within the concentration range 5 X 10(-6) to 1 X 10(-3) mol. l-1. In combination with THIO-TEPA its effect on chromosome aberration yields was additive. Styrene oxide proved also to be a very potent inducer of sister chromatid exchanges (SCE) within the concentration range 5 X 10(-6) to 1 X 10(-3) mol. l-1 tested. Combined with THIO-TEPA it exhibited a distinct additive effect in the production of SCEs. |
| Pmid | 6443360 |
| Wosid | MEDLINE:6443360 |
| Url | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022391218&partnerID=40&md5=8a162adb86c9b8fed35c571871ce2c04 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | <?xml version="1.0" encoding="UTF-8"?><kw>DCN-141466</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Cytotoxic effects</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Humans</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Blood analysis</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Lymphocytes</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>In vitro studies</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Styrene resins</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Oxides</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Mutagenicity</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Cell metabolism</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Chromosome disorders</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Genetics</kw> |
| Relationship(s) |
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