Teratogenicity of a group of phthalate esters in rats
HERO ID
61709
Reference Type
Technical Report
Subtype
TSCA Submission
Year
1983
Language
English
| HERO ID | 61709 |
|---|---|
| Material Type | TSCA Submission |
| Year | 1983 |
| Title | Teratogenicity of a group of phthalate esters in rats |
| Authoring Organization | University of Tennessee |
| Publisher Text | E. I. du Pont de Nemours & Company |
| City | Wilmington, DE |
| Abstract | In the past it has been demonstrated that small quantities of phthalates may be released from polyvinyl chloride items to physiological solutions. To ascertain the effect these plasticizers might have upon the fetus, a teratogenic study was undertaken in rats using eight phthalate esters. Six of the phthalates, whose acute, i.p. LD50 values were below 10 ml/Kg., were administered to rats at doses representing 1/10, 1/5 and 1/3 of the acute LD50 dose on the 5th, 10th and 15th day of gestation. while the two less toxic compounds were injected at a level of 5 and 10 ml/Kg. Distilled water and normal saline were tested at 10 ml/Kg., and cottonseed oil at 5 and 10 ml/Kg. Untreated animals were used for control values. The number of corpora lutea ranged from 52 to 65 per group of 5 rats. with no apparent distribution according to treatment. Embryo-fetal toxicity ranged from 0% to a high of 98.2%. Petal malformations ranged from 0% to 100%. both for gross and skeletal abnormalities, with skeletal defects generally being more common. Fetuses from all phthalate-treated groups were smaller (P = 0.01) than the untreated controls. Absence of tail, anophthalmia and twisted hind legs were the most common gross abnormalities, while elongated and fused ribs and abnormal skull bones were the most common deformities found in stained skeletal specimens. |
| Report Number | EPA/OTS Doc #878213812 |
| Ntis Number | OTS0206451 |
| Tscats Number | TSCATS/020789 |
| Url | https://ntrl.ntis.gov/NTRL/dashboard/searchResults/titleDetail/OTS0206451.xhtml |
| Is Certified Translation | No |
| Dupe Override | No |
| Number Of Pages | 24 |
| Comments | This report was also published as an abstract (1971), a journal article (1972), and submitted by DuPont under TSCA (1983). Report is found in the report package provided in the URL link. |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |