Toxic activity of seventeen industrial solvents and halogenated compounds on human lymphocytes cultured in vitro
Perocco, P; Bolognesi, S; Alberghini, W
HERO ID
628879
Reference Type
Journal Article
Year
1983
Language
English
PMID
| HERO ID | 628879 |
|---|---|
| In Press | No |
| Year | 1983 |
| Title | Toxic activity of seventeen industrial solvents and halogenated compounds on human lymphocytes cultured in vitro |
| Authors | Perocco, P; Bolognesi, S; Alberghini, W |
| Journal | Toxicology Letters |
| Volume | 16 |
| Issue | 1-2 |
| Page Numbers | 69-75 |
| Abstract | Seventeen chemicals (solvents, insecticides and intermediates in the production of textiles and resins) were tested in a short-term in vitro system with human lymphocytes to determine their toxic action. The parameters studied were the tritiated thymidine uptake and cell viability in cultures grown with or without a rat liver metabolizing system (S-9 mix). Data obtained showed that 1,3-dichlorobenzene, 1,2-dichlorobenzene, hexane, 1,2-diiodoethane, 1,4-dichlorobenzene, tetrachloroethylene, 2,3-dibromopropanol, chloromethyl methyl ether, 1,2- and 1,3-dibromopropane, in order, exerted the more toxic effects; ethyl acetate, cyclohexane, cyclohexanone and benzene showed lower toxic activity. The chemicals lost their toxic power in the presence of the metabolizing system with the exception of 1,2- and 1,3-dichlorobenzene which maintained in some degree their toxicity even in the presence of the S-9 mix. Only chloromethyl methyl ether elicited unscheduled DNA synthesis acting as DNA damaging agent. |
| Doi | 10.1016/0378-4274(83)90012-7 |
| Pmid | 6836616 |
| Wosid | WOS:A1983QF83700011 |
| Url | http://www.sciencedirect.com/science/article/pii/0378427483900127 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | DNA damage; DNA synthesis inhibition; insecticides |
| Relationship(s) |
|