Is 1,4-dioxane a genotoxic carcinogen?
Kitchin, KT; Brown, JL
HERO ID
62928
Reference Type
Journal Article
Year
1990
Language
English
PMID
| HERO ID | 62928 |
|---|---|
| In Press | No |
| Year | 1990 |
| Title | Is 1,4-dioxane a genotoxic carcinogen? |
| Authors | Kitchin, KT; Brown, JL |
| Journal | Cancer Letters |
| Volume | 53 |
| Issue | 1 |
| Page Numbers | 67-71 |
| Abstract | Female Sprague-Dawley rats were given 0, 168, 840, 2550 or 4200 mg/kg of 1,4-dioxane 21 and 4 h before sacrifice. Hepatic DNA damage (by the alkaline elution technique), ornithine decarboxylase activity (ODC), reduced glutathione content, cytochrome P-450 content and serum alanine aminotransferase activity (ALT) were determined. Treatment with 1,4-dioxane increased hepatic DNA damage and cytochrome P-450 content at doses of 2550 and 4200 mg/kg. Large increases in the activity of hepatic ODC were observed at 840, 2550 and 4200 mg/kg of 1,4-dioxane. Thus the data suggest that 1,4-dioxane is a weak genotoxic carcinogen in addition to being a strong promoter of carcinogenesis (a non-genotoxic carcinogen). |
| Doi | 10.1016/0304-3835(90)90012-M |
| Pmid | 2397485 |
| Wosid | WOS:A1990DZ12000011 |
| Url | https://linkinghub.elsevier.com/retrieve/pii/030438359090012M |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Cancer Lett. (Shannon, Irel.) 53: 67-71. |
| Is Public | Yes |
| Language Text | English |
| Keyword | 1,4-dioxane; promotion; DNA damage; ornithine decarboxylase; initiation; hepatocarcinogenesis |
| Is Qa | No |