1,4-Dioxane: Correlation of the results of chronic ingestion and inhalation studies with its dose-dependent fate in rats
Kociba, RJ; Torkelson, TR; Young, JD; Gehring, PJ
| HERO ID | 62930 |
|---|---|
| Year | 1975 |
| Title | 1,4-Dioxane: Correlation of the results of chronic ingestion and inhalation studies with its dose-dependent fate in rats |
| Book Title | Proceedings of the 6th Annual Conference on Environmental Toxicology |
| Authors | Kociba, RJ; Torkelson, TR; Young, JD; Gehring, PJ |
| Publisher Text | Wright-Patterson Air Force Base, Air Force Systems Command, Aerospace Medical Division, Aerospace Medical Research Laboratory |
| City | Wright-Patterson Air Force Base, OH |
| Page Numbers | 345-354 |
| Abstract | Dioxane (1,4-dioxane) is a colorless liquid used as a specialty solvent since about 1930. The prinicipal toxic effects of dioxane have long been known to be centrilobular, hepatocellular and renal tubular epithelial degeneration and necrosis (DeNavasquex, 1935; Fairley et al., 1934; Schrenk and Yant, 1936; Kesten et al., 1939). More recent reports by Argus et al. (1965) and Hoch-Ligeti et al.(1970) described nasal and hepatic carcinomas in rats ingesting water containing massive doses (up to 1.8% in the drinking water) of dioxane for over 13 months. Due to the massive doses which the rats received in these more recent studies, it is difficult to use the information to assess the hazard which may be incurred by individuals exposed to lower, more realistic levels of dioxane. Thus, a series of experiments has been conducted in our laboratory. This series has included a study of rats ingesting various dose levels of dioxane in the drinking water for 2 years (kociba et al., 1974), a study of rat exposed to vapors of dioxane for 2 years (Torkelson et al., 1974), and a study of the pharmacokinetics and metabolism of various dose levels of dioxane (Young et al. 1975). |
| Url | https://ntrl.ntis.gov/NTRL/dashboard/searchResults.xhtml?searchQuery=ADA024899 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Need copy of publication details.In: Proceedings of the sixth conference on environmental toxicology. Aerospace Medical Research Laboratory; pp. 345-354; technical report AMRL-TR-75-125; paper no. 19. Conference date: October 21-23, 1975 |
| Is Public | Yes |
| Is Qa | No |