Mutagenic and reproductive studies of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) in rats and rabbits
Minor, JL; Short, RD, Jr; Van Goethem, DL; Wong, LCK; Dacre, JC
HERO ID
630116
Reference Type
Book/Book Chapter
Subtype
Abstract
Year
1982
| HERO ID | 630116 |
|---|---|
| Material Type | Abstract |
| Year | 1982 |
| Title | Mutagenic and reproductive studies of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) in rats and rabbits |
| Authors | Minor, JL; Short, RD, Jr; Van Goethem, DL; Wong, LCK; Dacre, JC |
| Volume | 2 |
| Page Numbers | 34-35 |
| Abstract | Studies were conducted with RDX to evaluate the mutagenic effects (Ames Salmonella/microsome test dominant lethal assay) and reproductive effects (teratology, two-generation reproduction) in Charles River CD rats and New Zealand white rabbits. Mutagenic studies. RDX produced numbers of revertants similar to those in vehicle-treated controls at doses up to 1 mg/plate in all five strains of S. typhimurium, both without and with activation with the S-9 fraction (Aroclor 1254). Groups of male rates from the F0 reproduction study were fed RDX diets containing 0, 5, 16, or 50 mg/kg/day for 13 weeks and then mated with virgin females. There was no evidence of either a preimplantation loss of blastocysts or a post-implantation loss of embryos. RDX therefore is not mutagenic in the Ames and dominant lethal tests. Reproductive studies. Animals were given RDX suspensions by gavage at dose levels of 0, 0.2, 2.0 and 20 mg/kg/day; rats on days 6 to 19 and rabbits on days 7 to 29 of gestation. RDX was not teratogenic to rats and rabbits although maternal toxicity (neurotoxicity), lethality and embryotoxicity were seen in the high dose rats. No effects were seen at the 2 mg/kg level. Four groups of rats (22/sex/group) were fed RDX diets at levels of 0, 5, 16, and 50 mg/kg for 13 weeks and then mated. The F1 generations (26/sex/group) were similarly mated after 13 weeks on the diets. Reproduction was adversely affected only in the high dose group; fertility, viability and lactation indexes were reduced. |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Name | Society of Toxicology Annual Meeting |
| Is Public | Yes |
| Is Qa | No |