The distribution and metabolism of cyclotrimethylenetrinitramine (RDX) in the rat after subchronic administration
Schneider, NR; Bradley, SL; Andersen, ME
| HERO ID | 630122 |
|---|---|
| In Press | No |
| Year | 1978 |
| Title | The distribution and metabolism of cyclotrimethylenetrinitramine (RDX) in the rat after subchronic administration |
| Authors | Schneider, NR; Bradley, SL; Andersen, ME |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 46 |
| Issue | 1 |
| Page Numbers | 163-171 |
| Abstract | Rats were either dosed with unlabeled cyclotrimethylenetrinitramine (RDX) or [14C]RDX by gavage at 20 mg/kg/day for up to 90 days or allowed free access to unlabeled RDX or [14C]RDX-saturated drinking water (50-70 microg/ml) for up to 90 days. RDX did not accumulate in any tissue examined in these studies, nor were there any tendencies for plasma (RDX) to increase continuously with repeated dosing. In the 90-day drinking water study the daily recovery of the 14C label, estimated at the end of 1, 4, 8, and 13 weeks, varied between 54 and 89%. The majority of the label was excreted as exhaled 14CO2 and as unidentified metabolites in the urine. Residual carcass radioactivity in the drinking water study did increase threefold from Week 1 to Week 13. While no overt neurological signs characteristic of RDX toxicity occurred in any of the treated rats, 8 of 30 rats dosed with 20 mg/kg/day died, apparently from exacerbation of chronic respiratory disease. Compared with results from other animal studies, these data support an ingestion limit of 0.1 mg of RDX/kg/day, or an acceptable level of 2 to 3 ppm in potable water. |
| Doi | 10.1016/0041-008X(78)90147-3 |
| Url | http://linkinghub.elsevier.com/retrieve/pii/0041008X78901473 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Is Qa | No |