Deposition and retention of 0.1 μm 67Ga2O3 aggregate aerosols in rats following whole body exposures
Wolff, RK; Griffis, LC; Hobbs, CH; McClellan, RO
HERO ID
63812
Reference Type
Journal Article
Year
1982
Language
English
PMID
| HERO ID | 63812 |
|---|---|
| In Press | No |
| Year | 1982 |
| Title | Deposition and retention of 0.1 μm 67Ga2O3 aggregate aerosols in rats following whole body exposures |
| Authors | Wolff, RK; Griffis, LC; Hobbs, CH; McClellan, RO |
| Journal | Toxicological Sciences |
| Volume | 2 |
| Issue | 4 |
| Page Numbers | 195-200 |
| Abstract | Determinations were made of respiratory tract deposition and gastrointestinal tract burdens following whole body inhalation exposures, typical of those used in many chronic exposures; these were compared to values obtained in nose-only exposures. Fischer-344 rats were exposed in large volume chambers, in a whole body mode, to 0.1 μm volume median diameter (VMD) 67Ga2O3 particles 5 hrs/day. Deposition per unit of exposure time and retention were essentially identical following either 1 or 3 day exposures. The lung deposition of particles was 2.8 units/hr for males and 2.2 units/hr for females if the exposure concentration was expressed as 1 unit/L. These values represent a deposition of approximately 15% of the inhaled particles, similar to values obtained for nose-only exposures. Aerosol deposition per kgm body weight was 24% higher in females than males. Passage of material into the gastrointestinal tract was 1.6-fold greater for these whole body exposures as compared to nose-only exposures to the same aerosol mainly resulting from extra material ingested by grooming of the pelt. Approximately 60% of the pelt burden was calculated to be ingested following whole body exposures. |
| Doi | 10.1016/s0272-0590(82)80046-8 |
| Pmid | 7185617 |
| Wosid | MEDLINE:7185617 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |