Improved brachial artery shear patterns and increased flow-mediated dilatation after low-volume high-intensity interval training in type 2 diabetes
Ghardashi Afousi, A; Izadi, MR; Rakhshan, K; Mafi, F; Biglari, S; Gandomkar Bagheri, H
| HERO ID | 6388608 |
|---|---|
| In Press | No |
| Year | 2018 |
| Title | Improved brachial artery shear patterns and increased flow-mediated dilatation after low-volume high-intensity interval training in type 2 diabetes |
| Authors | Ghardashi Afousi, A; Izadi, MR; Rakhshan, K; Mafi, F; Biglari, S; Gandomkar Bagheri, H |
| Journal | Experimental Physiology |
| Volume | 103 |
| Issue | 9 |
| Page Numbers | 1264-1276 |
| Abstract | <strong>NEW FINDINGS: </strong>What is the central question of this study? Can low-volume high-intensity interval training and continuous moderate-intensity exercise modulate oscillatory and retrograde shear, blood flow and flow-mediated arterial dilatation in patients with type 2 diabetes? What is the main finding and its importance? Low-volume high-intensity interval training, by increasing anterograde shear and decreasing retrograde shear and oscillatory index, can increase nitric oxide production and consequently result in increased flow-mediated dilatation and outward arterial remodelling in patients with type 2 diabetes.<br /><br /><strong>ABSTRACT: </strong>Atherosclerosis in patients with type 2 diabetes is characterized by endothelial dysfunction associated with impaired flow-mediated dilatation (FMD) and increases retrograde and oscillatory shear. The present study investigated endothelium-dependent vasodilatation and shear rate in patients with type 2 diabetes at baseline and follow-up after 12 weeks of low-volume high-intensity interval training (LV-HIIT) or continuous moderate-intensity training (CMIT). Seventy-five sedentary patients with type 2 diabetes and untreated pre- or stage I hypertension were randomly divided into LV-HIIT, CMIT and control groups. The LV-HIIT group intervention was 12 intervals of 1.5 min at 85-90% maximal heart rate (HRmax ) and 2 min at 55-60% HRmax . The CMIT group intervention was 42 min of exercise at 70% HRmax for three sessions per week during 12 weeks. High-resolution Doppler ultrasound was used to measure FMD, arterial diameter, anterograde and retrograde blood flow, and shear rate patterns. Brachial artery FMD increased significantly in the LV-HIIT group (3.83 ± 1.13 baseline, 7.39 ± 3.6% follow-up), whereas there was no significant increase in the CMIT group (3.45 ± 0.97 baseline, 4.81 ± 2.36% follow-up) compared to the control group (3.16 ± 0.78 baseline, 4.04 ± 1.28% follow-up) (P < 0.05). Retrograde shear in the LV-HIIT group decreased significantly (P < 0.05), and no significant decrease in retrograde shear was seen in the CMIT group. Anterograde shear after LV-HIIT increased significantly (P < 0.05) but was unchanged in the CMIT group. However, oscillatory shear index in both exercise groups decreased significantly (P = 0.029). Nitrite/nitrate (NOx) level increased in both exercise groups, but the increase was greater in the LV-HIIT group (P < 0.001). The results indicate that by increasing NOx, HIIT decreases the oscillatory shear-induced improvement in FMD and outward artery remodelling in patients with type 2 diabetes. |
| Doi | 10.1113/EP087005 |
| Pmid | 29932275 |
| Wosid | WOS:000443227700012 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |