Possible mechanisms to explain dust overloading of the lungs
Morrow, PE
HERO ID
63994
Reference Type
Journal Article
Subtype
Review
Year
1988
Language
English
PMID
| HERO ID | 63994 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 1988 |
| Title | Possible mechanisms to explain dust overloading of the lungs |
| Authors | Morrow, PE |
| Journal | Toxicological Sciences |
| Volume | 10 |
| Issue | 3 |
| Page Numbers | 369-384 |
| Abstract | This paper briefly reviews the available evidence on dust overloading of the lungs. a condition which has come to the forefront in many recently reported chronic inhalation studies. A general hypothesis is developed that dust overloading, which is typified by a progressive reduction of particle clearance from the deep lung, reflects a breakdown in alveolar macrophage (AM)-mediated dust removal due to the loss of AM mobility. The inability of the dust-laden AMs to translocate to the mucociliary escalator is correlated to an average composite particle volume per alveolar macrophage in the lung, When this particulate volume exceeds approximately 60 Ám3/AM, on the basis of a uniform distribution of particles over the AM pool size (-2.5 X 10(7) cells) in the Fischer 344 rat, the overload effect appears to be initiated. When the distributed particulate volume exceeds -600 Ám3 per cell, the evidence suggests that AM-mediated particle clearance virtually ceases and agglomerated particle-laden macrophages remain in the alveolar region. This paper considers possible mechanisms why these particle-laden cells are immobilized, viz., one is based on excessive particle-cell, cell-cell chemotactic interactions, and migratory inhibition factors; the other considers the volumetric increase by phagocytized particles, per se, as leading to an inability of the AM to spread and migrate probably through a competitive requirement for surface membrane and cytoskeleton in both endocytotic and migratory functions. |
| Doi | 10.1016/0272-0590(88)90284-9 |
| Pmid | 3286345 |
| Wosid | WOS:A1988M776300001 |
| Url | https://linkinghub.elsevier.com/retrieve/pii/0272059088902849 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |