Organochlorine compounds, iodine intake, and thyroid hormone levels during pregnancy
Alvarez-Pedrerol, M; Guxens, M; Ibarluzea, J; Rebagliato, M; Rodriguez, À; Espada, M; Goñi, F; Basterrechea, M; Sunyer, J
HERO ID
644434
Reference Type
Journal Article
Year
2009
Language
English
PMID
| HERO ID | 644434 |
|---|---|
| In Press | No |
| Year | 2009 |
| Title | Organochlorine compounds, iodine intake, and thyroid hormone levels during pregnancy |
| Authors | Alvarez-Pedrerol, M; Guxens, M; Ibarluzea, J; Rebagliato, M; Rodriguez, À; Espada, M; Goñi, F; Basterrechea, M; Sunyer, J |
| Journal | Environmental Science & Technology |
| Volume | 43 |
| Issue | 20 |
| Page Numbers | 7909–7915 |
| Abstract | The effect of organochlorine compounds (OCs) on thyroid function, as well as the potential confounding effect of iodine intake, was studied in a large sample of pregnant women from two population-based cohort studies in Sabadell (n = 520) and Gipuzkoa (n = 570), Spain. Thyroid hormones (free T4 and total T3), thyrotropin, and polychlorinated biphenyls (PCB congeners 118, 138, 153, and 180), hexachlorobenzene (HCB), beta-hexachlorocyclohexane (beta-HCH), dichlorodiphenyl dichloroethylene (p'p'-DDE) and dichlorodiphenyl richloroethane (p'p-DDT) were measured in serum samples collected at first trimester of pregnancy. Urinary iodine concentration (UIC) was measured and iodine intake from diet, iodized salt, and supplements were estimated from a food frequency questionnaire. Levels of HCB and PCBs congeners 180, 153, and 138 were related to lowe rtotal T3 levels (adjusted coefficient (SE): -4.0(1.1), -6.1(1.6), -5.5(1.6), and 3.8(1.4), respectively) and higher free T4 levels (adjusted coefficient (SE): 0.013(0.05), 0.017(0.007), 0.016(0.007), and 0.007(0.006), respectively). These associations were homogeneous in both cohorts, especially for PCBs and total T3 (p-value forthe interaction between cohorts >0.8). Iodine intake and UIC did not affect the association between OCs and thyroid hormones. Our results indicate that exposure to OCs during pregnancy can alter TH levels. |
| Doi | 10.1021/es9007273 |
| Pmid | 19921913 |
| Wosid | WOS:000270594900053 |
| Url | https://search.proquest.com/docview/230160057?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Environmental Studies; Chemical compounds; Thyroid gland; Pregnancy; Hormones |
| Is Qa | No |