Octachloronaphthalene
| HERO ID | 644627 |
|---|---|
| Year | 1991 |
| Title | Octachloronaphthalene |
| Book Title | Documentation of the threshold limit values and biological exposure indices |
| Authoring Organization | American Conference of Governmental Industrial Hygienists |
| Publisher Text | American Conference of Governmental Industrial Hygienists |
| City | Cincinnati, OH |
| Volume | II |
| Page Numbers | 1141-1142 |
| Abstract | TLV Recommendation Exposure of animals to chlorinated naphthalenes has produced severe liverinjury and skin absorption has been suggested. In oral administration experiments with animals, octachloronaphthalene has caused hyperkeratosis; on the skin of human volunteers itwas entirely nonacneigenic. Sikes et al.(3> concluded from ingestion experiments in cattle that, for chlorinated naphthalenes, the greater the degree of chlorination, the more toxic the compound. Accordingly, by analogy with hexachloro naphthalene (TLV-TWA 0.2 mg/m3, skin), a TLV-TWA of 0.1 mg/m3 and a STEL of 0.3 mg/m3, with a skin notation, are recommended for octachloronaphthalene. These values should minimize the risk of liver injury and the potential for percutaneous absorption and skin toxic ity. Deletion of the STEL is being considered by the TLV Committee. |
| Is Certified Translation | No |
| Dupe Override | No |
| Edition | Sixth |
| Is Public | Yes |
| Is Qa | No |