Selenium supplementation decreases hepatic fibrosis in mice after chronic carbon tetrachloride administration
Ding, M; Potter, JJ; Liu, X; Torbenson, MS; Mezey, E
HERO ID
652482
Reference Type
Journal Article
Year
2010
Language
English
PMID
| HERO ID | 652482 |
|---|---|
| In Press | No |
| Year | 2010 |
| Title | Selenium supplementation decreases hepatic fibrosis in mice after chronic carbon tetrachloride administration |
| Authors | Ding, M; Potter, JJ; Liu, X; Torbenson, MS; Mezey, E |
| Journal | Biological Trace Element Research |
| Volume | 133 |
| Issue | 1 |
| Page Numbers | 83-97 |
| Abstract | Oxidative stress stimulates fibrogenesis, and selenium (Se) has antioxidant properties. This study determined whether Se supplementation affects CCl(4)-induced liver injury and fibrosis. Mice were administered CCl(4) over 4 weeks, while controls received olive oil. Se was provided as sodium selenite in the drinking water. Se increased liver Se-dependent glutathione peroxidase activity and decreased liver malondialdehyde after CCl(4). Se decreased liver inflammation but not necrosis caused by CCl(4). Se increased hepatocyte apoptosis after CCl(4) and the pro-apoptotic BAX and Bcl Xs/l proteins. Stellate cell apoptosis occurred only after CCl(4) in Se-supplemented mice. Se decreased stellate cell number and fibrosis after CCl(4). Liver matrix metalloproteinase-9 increased after CCl(4) with Se supplementation. In conclusion, Se supplementation decreased hepatic fibrosis after CCl(4) in the setting of decreased inflammation but increased apoptosis. The principal mechanisms for the decreased fibrosis are a lower number of collagen-producing stellate cells and increased collagen degradation. |
| Doi | 10.1007/s12011-009-8414-x |
| Pmid | 19488682 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Animals; *Carbon Tetrachloride/toxicity; *Carbon Tetrachloride Poisoning; *Dietary Supplements; Liver/*drug effects/injuries; Liver Cirrhosis/chemically induced; Male; Mice; Mice, Inbred C57BL; Reference Standards; Selenium/administration & dosage/*pharmacology |
| Is Qa | No |