Setting an indoor air exposure limit for formaldehyde: factors of concern
Arts, JH; Muijser, H; Kuper, CF; Woutersen, RA
HERO ID
655718
Reference Type
Journal Article
Year
2008
Language
English
PMID
| HERO ID | 655718 |
|---|---|
| In Press | No |
| Year | 2008 |
| Title | Setting an indoor air exposure limit for formaldehyde: factors of concern |
| Authors | Arts, JH; Muijser, H; Kuper, CF; Woutersen, RA |
| Journal | Regulatory Toxicology and Pharmacology |
| Volume | 52 |
| Issue | 2 |
| Page Numbers | 189-194 |
| Abstract | The paper aims to evaluate the indoor air limit of 1 microg/m(3) (0.8 ppb) formaldehyde as advised by the European Commission [the INDEX project; Kotzias, D., Koistinen, K., Kephalopoulos, S., Schlitt, C., Carrer, P., Maroni, M., Jantunen, M., Cochet, C., Kirchner, S., Lindvall, T., McLaughlin, J., Molhave, L., de Oliveira Fernandes, E., Seifert, B., 2005. Critical appraisal of the setting and implementation of indoor exposure limits in the EU. European Commission, Institute for Health and Consumer Protection, Physical and Chemical Exposure Unit, Ispra, Italy, pp. 1-50]. The limit has been based on a nose and throat irritation threshold of 0.1mg/m(3) (0.08 ppm; LOAEL), a NOAEL of 0.03 mg/m(3) (0.025 ppm) and an assessment factor of 30, including a factor of 3 for the higher sensitivity of children. Nose and throat irritation, at concentrations below which hyperplasia/metaplasia occurs, are most likely the manifestation of trigeminal nerve stimulation (sensory irritation). The threshold for sensory irritation in human volunteers is 1 ppm, much higher than the 0.1mg/m(3) indicated above. Eye irritation is the most sensitive effect reported in human volunteers but has been mentioned only occasionally in the studies used by the European Commission. Moreover, sensory irritation is a local reaction that requires a low assessment factor, if any. It is difficult to judge the sensitivity for sensory irritation in children because of the potential confounding factors in the evaluated studies. It is concluded that an indoor air level of 0.1 ppm (0.12 mg/m(3)) formaldehyde, as indicated by Appel et al. (2006) [Appel, K.E., Bernauer, U., Herbst, U., Madle, S., Schulte, A., Richter-Reichhelm, H.B., Gundert-Remy, U. 2006. Kann fur Formaldehyd eine "sichere" Konzentration abgeleitet werden?--Analyse der Daten zur krebserzeugenden Wirkung (Can a "safe" concentration be established for formaldehyde?--Analysis of carcinogenicity data)? Umweltmed. Forsch. Prax. 11, 347-361], can be considered a safe and appropriate level. |
| Doi | 10.1016/j.yrtph.2008.08.009 |
| Pmid | 18786592 |
| Wosid | WOS:000261578800017 |
| Url | <Go to ISI>://WOS:000261578800017 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000261578800017 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Administration, Inhalation; Air Pollutants/*toxicity; Carcinogens/administration & dosage/toxicity; Child; European Union; Eye/drug effects/pathology; Formaldehyde/administration & dosage/*toxicity; Humans; Inhalation Exposure/*adverse effects; Irritants/administration & dosage/*toxicity; No-Observed-Adverse-Effect Level; Nose/drug effects/pathology; Occupational Exposure/adverse effects; Pharynx/drug effects/pathology; Trigeminal Nerve/drug effects/metabolism; 0 (Air Pollutants); 0 (Carcinogens); 0 (Irritants); 50-00-0 (Formaldehyde) |
| Is Qa | No |