Enantioselective Friedel-Crafts alkylation reaction of indoles with alpha,beta-unsaturated acyl phosphonates catalyzed by chiral phosphoric acid
Bachu, P; Akiyama, T
| HERO ID | 658445 |
|---|---|
| In Press | No |
| Year | 2010 |
| Title | Enantioselective Friedel-Crafts alkylation reaction of indoles with alpha,beta-unsaturated acyl phosphonates catalyzed by chiral phosphoric acid |
| Authors | Bachu, P; Akiyama, T |
| Journal | Chemical Communications |
| Volume | 46 |
| Issue | 23 |
| Page Numbers | 4112-4114 |
| Abstract | A variety of indoles underwent enantioselective Friedel-Crafts alkylation with alpha,beta-unsaturated acyl phosphonates in the presence of 10 mol% chiral BINOL-based phosphoric acid and subsequent treatment with methanol and DBU to give methyl 3-(indol-3-yl)propanoates in good yields and with high enantioselectivities. |
| Doi | 10.1039/c000862 |
| Pmid | 20520877 |
| Wosid | WOS:000278364900023 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science 000278364900023 |
| Is Public | Yes |
| Language Text | English |
| Is Qa | No |