Toxicology of coal liquefaction products: an overview
Chu, L; Villeneuve, DC; Rousseaux, CG
HERO ID
6611
Reference Type
Journal Article
Subtype
Review
Year
1994
Language
English
PMID
| HERO ID | 6611 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 1994 |
| Title | Toxicology of coal liquefaction products: an overview |
| Authors | Chu, L; Villeneuve, DC; Rousseaux, CG |
| Journal | Journal of Applied Toxicology |
| Volume | 14 |
| Issue | 4 |
| Page Numbers | 241-256 |
| Abstract | Repeated exposure to coal liquefaction products produces a broad range of systemic effects. Among these, growth suppression, anaemia, leucocytosis and other haematological disorders are most prominent. Bone marrow, liver and kidney are the target organs affected by treatment. The effects are more severe with heavy distillates and male rats are more sensitive than females. Other changes included increased serum transaminases, alkaline phosphatase and cholesterol. Depending on the route of administration, the skin or lung may also be affected. Inhalation exposure produces the most severe changes, and oral exposure the least. Distillates containing N-PAHs and sulphur-containing PAHs are also more biologically active. Teratological effects were only observed if animals were exposed to the heavy distillate. Similarly, heavy distillates have mutagenic or carcinogenic properties. Teratological effects, as well as mutagenicity and carcinogenicity, of the coal liquefaction distillates seem to be linked to their PAH content, especially the N-PAHs. From the data presented in this review, it should become evident that the potential effects of coal liquefaction products on human health could be severe, especially with long-term exposure. Limited information exists on the occupational effects to coal liquefaction materials because most of the work to date has been with pilot plants. Careful and good judgement is required in order to extrapolate data from pilot plants to commercial-scale production. Experience in health effects of workers in the petroleum industry and coke-oven operations can serve as a guide for the implementation of industrial hygiene programmes for coal liquefaction operations. These programmes include engineering controls, health education, personal monitoring and hygienic practices, medical surveillance and long-term epidemiology studies, and they should be implemented to make coal liquefaction a healthy and environmentally sustainable industry. |
| Doi | 10.1002/jat.2550140402 |
| Pmid | 7963236 |
| Wosid | WOS:A1994PA65500001 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | <?xml version="1.0" encoding="UTF-8"?><kw>Biochemical Studies-General</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Biochemical Studies-Nucleic Acids</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Respiratory System-General</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Integumentary System-General</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Dental and Oral Biology-General</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Routes of Immunization</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Toxicology-Environmental and Industrial Toxicology</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Neoplasms and Neoplastic Agents-Carcinogens and Carcinogenesis</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Developmental Biology-Embryology-Descriptive Teratology and Teratogenesis</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Public Health: Environmental Health-Air</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Mammalia-Unspecified</kw> |
| Relationship(s) |
|