Fragrances and other materials in deodorants: Search for potentially sensitizing molecules using combined GC-MS and structure activity relationship (SAR) analysis
Rastogi, SC; Lepoittevin, JP; Johansen, JD; Frosch, PJ; Menne, T; Bruze, M; Dreier, B; Andersen, KE; White, IR
| HERO ID | 665279 |
|---|---|
| In Press | No |
| Year | 1998 |
| Title | Fragrances and other materials in deodorants: Search for potentially sensitizing molecules using combined GC-MS and structure activity relationship (SAR) analysis |
| Authors | Rastogi, SC; Lepoittevin, JP; Johansen, JD; Frosch, PJ; Menne, T; Bruze, M; Dreier, B; Andersen, KE; White, IR |
| Journal | Contact Dermatitis |
| Volume | 39 |
| Issue | 6 |
| Page Numbers | 293-303 |
| Abstract | Deodorants are one of the most frequently-used types of cosmetics and are a source of allergic contact dermatitis. Therefore, a gas chromatography - mass spectrometric analysis of 71 deodorants was performed for identification of fragrance and non-fragrance materials present in marketed deodorants. Furthermore, the sensitizing potential of these molecules was evaluated using structure activity relationships (SARs) analysis. This was based on the presence of 1 or more chemically reactive site(s), in the chemical structure, associated with sensitizing potential. Among the many different substances used to formulate cosmetic products (over 3500), 226 chemicals were identified in a sample of 71 deodorants. 84 molecules were found to contain at least 1 structural alert, and 70 to belong to, or be susceptible to being metabolized into, the chemical group of aldehydes, ketones and alpha,beta-unsaturated aldehydes, ketone or esters. |
| Doi | 10.1111/j.1600-0536.1998.tb05944.x |
| Pmid | 9874020 |
| Wosid | WOS:000077759200004 |
| Is Certified Translation | No |
| Dupe Override | 665279 |
| Comments | Authoring Organization: GREEN SHIELD ECOLOGY INC |
| Is Public | Yes |
| Language Text | English |
| Keyword | Biochemistry methods; Biochemistry; Hypersensitivity |
| Relationship(s) |
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