RDX pilot development neurotoxicity test in rats
Hess-Ruth, A; Crouse, L; Roszell, L
| HERO ID | 670886 |
|---|---|
| Year | 2007 |
| Title | RDX pilot development neurotoxicity test in rats |
| Authors | Hess-Ruth, A; Crouse, L; Roszell, L |
| Publisher Text | U.S. Army Center for Health Promotion and Preventive Medicine |
| City | Aberdeen Proving Ground |
| Abstract | Hexahydro-1,3,5-trinitro-1,3,5-triazine (Royal Demolition Explosive or RDX) is an explosive nitroamine widely used in military and industrial applications. Contamination with RDX has been identified at areas of explosive manufacturing, processing, storage, and usage. Thus, the potential exists for explosure to humans. To determine a neurotoxic developmental effect the compound must first be transferred from themother to the offspring during gestation. This study was designed to determine if RDX would be passsed to the offspring during gestation as well as during lacatation. Female Sprague Dawley rats were dosed with RDX, 6 mg/kg on gestation day (GD) 6 through postnatal day (PND) 10. At PND 0, 3, 5, and 10 dams and pups were tested for RDX in the milk and brain, respectively. The results indicated that there was a significant amount of RDX present in the brain of the pups following parturition. RDX was also found in significant amounts in the milk during lactation. Given these data further studies evaluated the neurotoxic and developmental effects of RDX should be conducted. |
| Report Number | Toxicology Study No. 85-XC-064Y-07 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Protocol No. 064Y-60-06-12-01 |
| Is Public | Yes |
| Is Qa | No |