In vitro study of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) metabolism in human liver
Cao, CJ; Reddy, G; Bannon, DI; Johnson, MS
HERO ID
672731
Reference Type
Technical Report
Year
2008
Language
English
| HERO ID | 672731 |
|---|---|
| Year | 2008 |
| Title | In vitro study of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) metabolism in human liver |
| Authors | Cao, CJ; Reddy, G; Bannon, DI; Johnson, MS |
| Publisher Text | U.S. Army Center for Health Promotion and Preventive Medicine |
| City | Aberdeen Proving Ground, MD |
| Abstract | This project is the first to investigate RDX metabolism in human liver. RDX metabolism was screened in human liver tissues including S9 preparations, microsomes, hepatocytes and several recombinant CYP450 isoforms under aerobic, anaerobic and oxygen reduced conditions. RDX metabolism was also conducted in several animal liver microsomes to compare with hum an liver microsomes. loss of the parent compound (RDX) was determined at 30 and 180 minutes of the incubation and ranked as human (46.6% & 51.8%)> rat (40.1% & 47.2%)> monkey (34.6% & 35.7%)> Pig (25.5% & 33.7%)> rabbit (11.6% & 18.0). The data is used to establish Physiologically-based pharm acokinetic (PBPK) models for human useful in risk assessment. Further characterization of the profiles of RDX in vitro metabolism in human and animal liver tissues is proposed. This study developed an in vitro metabolic model which mimics in vivo physiological condition and will be useful in the evaluation of human metabolic fate for novel energetics such as replacement formulations for RDX and for other toxic TICs/TIMs. |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Toxicolgy study no. 87-XE-0982-09 |
| Is Public | Yes |
| Language Text | English |