Proposed mode of action for in utero effects of some phthalate esters on the developing male reproductive tract
David, RM
HERO ID
673617
Reference Type
Journal Article
Subtype
Review
Year
2006
Language
English
PMID
| HERO ID | 673617 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 2006 |
| Title | Proposed mode of action for in utero effects of some phthalate esters on the developing male reproductive tract |
| Authors | David, RM |
| Journal | Toxicologic Pathology |
| Volume | 34 |
| Issue | 3 |
| Page Numbers | 209-219 |
| Abstract | Phthalate esters containing a straight-chain backbone of 4-6 carbons have demonstrated testicular toxicity and infertility in adult and pre-adolescent rats, mice, hamsters, and ferrets. In recent years, these same phthalates have been shown to interfere with the normal development of the male reproductive tract in rodents and rabbits. The review presented here summarizes studies that provide evidence of a mode of action for these effects. The data indicate that C4-C6 phthalate esters inhibit processes in the Leydig cell, such as the synthesis of testosterone (T) and production of insulin-like factor 3 (insl3), both of which are required for normal development of male genitalia. A proposed secondary effect of reduced androgen production is on Sertoli cells, resulting in failure to proliferate and interference with cell-cell communication (gap-junction intracellular communication) leading to the development of large multinucleate gonocytes. The possibility that phthalates act directly on the Sertoli cells to interfere with intracellular communication is not excluded. The strength, consistency, and plausibility of the proposed mode of action and alternate modes of action are discussed. |
| Doi | 10.1080/01926230600642625 |
| Pmid | 16698716 |
| Wosid | WOS:000237512800001 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000237512800001 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Animals; Esters/toxicity; Female; Genitalia, Male/*drug effects/pathology; Humans; Leydig Cells/drug effects/metabolism; Male; *Maternal Exposure; Phthalic Acids/metabolism/*toxicity; Pregnancy; Sertoli Cells/drug effects/metabolism; Testosterone/metabolism; 0 (Esters); 0 (Phthalic Acids); 58-22-0 (Testosterone); 88-99-3 (phthalic acid) |