Peroxisome induction studies on seven phthalate esters
Barber, ED; Astill, BD; Moran, EJ; Schneider, BF; Gray, TJB; Lake, BG; Evans, JG
HERO ID
674933
Reference Type
Journal Article
Year
1987
Language
English
PMID
| HERO ID | 674933 |
|---|---|
| In Press | No |
| Year | 1987 |
| Title | Peroxisome induction studies on seven phthalate esters |
| Authors | Barber, ED; Astill, BD; Moran, EJ; Schneider, BF; Gray, TJB; Lake, BG; Evans, JG |
| Journal | Toxicology and Industrial Health |
| Volume | 3 |
| Issue | 2 |
| Page Numbers | 7-24 |
| Abstract | Seven phthalate esters, representing a variety of chain lengths and degrees of branching in the alcohol moiety, were tested for their ability to produce peroxisome proliferation in the Fischer 344 rat. Di(2-ethylhexyl)adipate (DEHA) was tested using the same protocol and di(2-ethylhexyl)phthalate (DEHP) was run with each study as an internal control. Each ester was administered in the feed for a period of 21 days at levels of 2.5%, 1.2% and either 0.6% or 0.3%. DEHP and DEHA were also fed at levels of 0.1% and 0.01%. The animals were sacrificed and samples of liver were prepared for both light and electron microscopy. Serum samples were assayed for both triglyceride and cholesterol. The remaining portion of the liver was homogenized and assayed for cyanide-insensitive palmitoyl-CoA oxidation, lauric acid 11-hydroxylase and lauric acid 12-hydroxylase. The results show that there is approximately a ten-fold difference between the weakest and strongest esters in terms of their potency to induce changes in relative liver weight and in several of the biochemical parameters. In general, the longer chain esters were more potent than the shorter chain ones, and branched chain esters seemed more potent than straight. Several statistical analyses of the dataset have been performed and all render similar conclusions. The results of one of these evaluations are presented elsewhere in this volume (Lin, 1987). |
| Doi | 10.1177/074823378700300203 |
| Pmid | 3617071 |
| Wosid | WOS:A1987H958700003 |
| Url | http://journals.sagepub.com/doi/10.1177/074823378700300203 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Proquest URL: https://search.proquest.com/docview/760216050?accountid=171501 Scopus URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023624224&doi=10.1177%2f074823378700300203&partnerID=40&md5=512ab6292d0115c568993a627a03e187 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Fischer 344 rat; peroxisome proliferation; phthalate esters; structure/activity relationships |
| Is Peer Review | Yes |
| Relationship(s) |