[Phthalates]
Saillenfait, AM; Laudet-Hesbert, A
| HERO ID | 675412 |
|---|---|
| In Press | No |
| Year | 2005 |
| Title | [Phthalates] |
| Authors | Saillenfait, AM; Laudet-Hesbert, A |
| Journal | Encyclopédie Médico-Chirurgicale. Toxicologie, Pathologie Professionnelle |
| Volume | 2 |
| Issue | 1 |
| Page Numbers | 1-13 |
| Abstract | Phthalic esters or organic phthalates consist of a family of chemicals that are widely used, mainly as PVC plasticizers for numerous consumer and industrial products. Their volatility and water solubility are low. This information note covers the six phthalates whose use is currently the most important. Among rodents, the main observed toxic effects concern the liver, and include liver tumours in the case of diisononyl phthalate and di-(2-ethylhexyl) phthalate. However, it is generally accepted that in view of the mode of action of these substances these effects cannot be extrapolated to humans. The effects of certain phthalates that are the cause of most concern relate to reproductive and pre-birth developmental effects: di-n-butyl phthalate, butyl benzyl phthalate and di-(2-ethylhexyl) phthalate can affect the male reproductive system (both during development and among adults) and are embryotoxic and foetotoxic. |
| Doi | 10.1016/j.emctp.2004.10.003 |
| Url | http://www.sciencedirect.com/science/article/pii/S176258580400027X |
| Is Certified Translation | No |
| Translated Title | Phtalates |
| Dupe Override | No |
| Comments | Authoring Organization: EG and G BIONOMICS |
| Is Public | Yes |
| Language Text | French |
| Keyword | France; phthalates; toxicology; animal experiments; antifertility effects; benzyl butyl phthalate; bis(ethylhexyl) phthalate; children; criteria document; data sheet; dibutyl phthalate; diisodecyl phthalate; dioctyl phthalate; embryotoxic effects; encyclopaedia; expectant mothers; literature survey; liver cancer; plasticizers; polyvinyl chloride; Toxic and dangerous substances; Safety, health and conditions of work; Chemical safety information sheets; 117-81-7; 117-84-0; 26761-40-0; 84-74-2; 85-68-7; 9002-86-2 |
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