Sex differences in the effects of vanadium pentoxide administration to prepubertal rats
Altamirano, M; Ayala, ME; Flores, A; Morales, L; Dominguez, R
| HERO ID | 677607 |
|---|---|
| In Press | No |
| Year | 1991 |
| Title | Sex differences in the effects of vanadium pentoxide administration to prepubertal rats |
| Authors | Altamirano, M; Ayala, ME; Flores, A; Morales, L; Dominguez, R |
| Journal | Medical Science Research |
| Volume | 19 |
| Issue | 23 |
| Page Numbers | 825-826 |
| Abstract | Vanadium pentoxide (V2O5) is the most toxic form of vanadium for mammals, presumably because of its inhibitory effects on several enzymes. We have previously demonstrated an increase in polyploid cell frequency and a decrease in the mitotic index of human lymphocytes treated in vitro with V2O5. The administration of metavanadate to adult rats induced impairment of spermatogenesis, and a decrease in the mobility of spermatozoa, while its administration to pregnant rats increased the mortality rate of embryos. In vitro orthovanadate inhibited luteinising: hormone-induced cyclic adenosine monophosphate (cAMP) in isolated corpora lutea from psuedopregnant rats. Since puberty is the result of several modifications in the mechanisms controlling gonadotrophin secretion and gonadal reactivity to them, we decided to compare the effects of V2O5 administered to male and female prepubertal rats. |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | eng |
| Keyword | <?xml version="1.0" encoding="UTF-8"?><kw>Cytology and Cytochemistry-Animal</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Biochemical Studies-General</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Biochemical Studies-Proteins</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Biochemical Studies-Carbohydrates</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Biochemical Studies-Minerals</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Metabolism-Carbohydrates</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Metabolism-Proteins</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Reproductive System-Pathology</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Endocrine System-Gonads and Placenta</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Endocrine System-Pituitary</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Toxicology-General</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Muridae</kw> |
| Is Qa | No |
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