Maternal-fetal transfer of 14C-di-2-ethylhexyl phthalate and 14C-diethyl phthalate in rats
Singh, AR; Lawrence, WH; Autian, J
HERO ID
682148
Reference Type
Journal Article
Year
1975
Language
English
PMID
| HERO ID | 682148 |
|---|---|
| In Press | No |
| Year | 1975 |
| Title | Maternal-fetal transfer of 14C-di-2-ethylhexyl phthalate and 14C-diethyl phthalate in rats |
| Authors | Singh, AR; Lawrence, WH; Autian, J |
| Journal | Journal of Pharmaceutical Sciences |
| Volume | 64 |
| Issue | 8 |
| Page Numbers | 1347-1350 |
| Abstract | 14C-Di-2-ethylhexyl and 14C-diethyl phthalates were administered intraperitoneally to pregnant rats on either Day 5 or 10 of gestation. Rats were sacrificed at 24-hr intervals starting on Days 8 and 11, respectively; maternal blood, fetal tissue, amniotic fluid, and placentas (whenever possible) were obtained. The 14C-activity of each sample was determined by scintillation counting. It was found that both diesters and/or their metabolic products were present in each of these compartments throughout the gestation period, thus suggesting that the embryo-fetal toxicity and teratogenesis reported previously could be the results of a direct effect of the compound (or its metabolites) upon developing embryonic tissue. Additionally, the reduction in concentration of 14C from these tissues as a function of time was found to fit a first-order excretion curve. From this model curve, the half-life for both compounds was calculated; the average was about 2.33 days for di-2-ethylhexyl phthalate and 2.22 days for diethyl phthalate. |
| Doi | 10.1002/jps.2600640819 |
| Pmid | 1151708 |
| Wosid | WOS:A1975AM14100015 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | ProQuest URL: https://search.proquest.com/docview/82939349?accountid=171501 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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