The descriptive epidemiology of congenital and acquired cryptorchidism in a UK infant cohort
Acerini, C; Miles, H; Dunger, D; Ong, K; Hughes, I
HERO ID
699453
Reference Type
Journal Article
Year
2009
Language
English
PMID
| HERO ID | 699453 |
|---|---|
| In Press | No |
| Year | 2009 |
| Title | The descriptive epidemiology of congenital and acquired cryptorchidism in a UK infant cohort |
| Authors | Acerini, C; Miles, H; Dunger, D; Ong, K; Hughes, I |
| Journal | Archives of Disease in Childhood |
| Volume | 94 |
| Issue | 11 |
| Page Numbers | 868-872 |
| Abstract | Recent studies in other European countries suggest that the prevalence of congenital cryptorchidism continues to increase. This study aimed to explore the prevalence and natural history of congenital cryptorchidism in a UK centre.<br /><br /> Between October 2001 and July 2008, 784 male infants were born in the prospective Cambridge Baby Growth Study. 742 infants were examined by trained research nurses at birth; testicular position was assessed using standard techniques. Follow-up assessments were completed at ages 3, 12, 18 and 24 months in 615, 462, 393 and 326 infants, respectively.<br /><br /> The prevalence of cryptorchidism at birth was 5.9% (95% CI 4.4% to 7.9%). Congenital cryptorchidism was associated with earlier gestational age (p<0.001), lower birth weight (p<0.001), birth length (p<0.001) and shorter penile length at birth (p<0.0001) compared with other infants, but normal size after age 3 months. The prevalence of cryptorchidism declined to 2.4% at 3 months, but unexpectedly rose again to 6.7% at 12 months as a result of new cases. The cumulative incidence of "acquired cryptorchidism" by age 24 months was 7.0% and these cases had shorter penile length during infancy than other infants (p = 0.003).<br /><br /> The prevalence of congenital cryptorchidism was higher than earlier estimates in UK populations. Furthermore, this study for the first time describes acquired cryptorchidism or "ascending testis" as a common entity in male infants, which is possibly associated with reduced early postnatal androgen activity. |
| Doi | 10.1136/adc.2008.150219 |
| Pmid | 19542061 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Is Qa | No |