Genotoxic activity of nitroaromatic explosives and related compounds in Salmonella typhimurium
Whong, W; Edwards, G
HERO ID
700000
Reference Type
Journal Article
Year
1984
Language
English
PMID
| HERO ID | 700000 |
|---|---|
| In Press | No |
| Year | 1984 |
| Title | Genotoxic activity of nitroaromatic explosives and related compounds in Salmonella typhimurium |
| Authors | Whong, W; Edwards, G |
| Journal | Mutation Research |
| Volume | 136 |
| Issue | 3 |
| Page Numbers | 209-215 |
| Abstract | A number of nitroaromatic explosives and related compounds were examined for mutagenic activity with the Salmonella/mammalian microsome test. 9 of 11 nitroaromatics tested were mutagenic, including 2,4,6-trinitrotoluene, the most widely produced military explosive. All the nitroaromatics, except 2,4,6-trinitrophenol and 2,3,5-trinitroresorcinol, were at least an order of magnitude more mutagenic than 3 dinitrotoluene (DNT) isomers. The most active compound was 2,3,5-trinitronaphthalene, which was approximately 5000 times more mutagenic than DNT isomers. These compounds induced predominantly frameshift mutations. The mutagenic activity did not require S9 activation, but was largely dependent on the presence of an intact nitroreductase capability in the test bacteria. This implied that reduced metabolites, possibly hydroxylamines, are the proximal mutagenic intermediates. |
| Doi | 10.1016/0165-1218(84)90054-5 |
| Pmid | 6377057 |
| Wosid | WOS:A1984SY90800006 |
| Url | <Go to ISI>://WOS:A1984SY90800006 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: MUTAT RES 136 ISSN:Scopus URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0021256345&doi=10.1016%2f0165-1218%2884%2990054-5&partnerID=40&md5=935fb4661b48a13b61522dde6ddcdba3 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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