Challenges associated with applying physiologically based pharmacokinetic modeling for public health decision-making
Tan, Y; Worley, RR; Leonard, JA; Fisher, JW
HERO ID
7004906
Reference Type
Journal Article
Subtype
Review
Year
2018
Language
English
PMID
| HERO ID | 7004906 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 2018 |
| Title | Challenges associated with applying physiologically based pharmacokinetic modeling for public health decision-making |
| Authors | Tan, Y; Worley, RR; Leonard, JA; Fisher, JW |
| Journal | Toxicological Sciences |
| Volume | 162 |
| Issue | 2 |
| Page Numbers | 341-348 |
| Abstract | The development and application of physiologically based pharmacokinetic (PBPK) models in chemical toxicology have grown steadily since their emergence in the 1980s. However, critical evaluation of PBPK models to support public health decision-making across federal agencies has thus far occurred for only a few environmental chemicals. In order to encourage decision-makers to embrace the critical role of PBPK modeling in risk assessment, several important challenges require immediate attention from the modeling community. The objective of this contemporary review is to highlight 3 of these challenges, including: (1) difficulties in recruiting peer reviewers with appropriate modeling expertise and experience; (2) lack of confidence in PBPK models for which no tissue/plasma concentration data exist for model evaluation; and (3) lack of transferability across modeling platforms. Several recommendations for addressing these 3 issues are provided to initiate dialog among members of the PBPK modeling community, as these issues must be overcome for the field of PBPK modeling to advance and for PBPK models to be more routinely applied in support of public health decision-making. |
| Doi | 10.1093/toxsci/kfy010 |
| Pmid | 29385573 |
| Wosid | WOS:000429021100003 |
| Url | https://academic.oup.com/toxsci/article/162/2/341/4827571 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | physiologically based pharmacokinetic model; good modeling practice; risk assessment; intraspecies extrapolation; interspecies extrapolation |