PGC-1 alpha, Inflammation, and Oxidative Stress: An Integrative View in Metabolism
Rius-Perez, S; Torres-Cuevas, I; Millan, I; Ortega, AL; Perez, S; ,
| HERO ID | 7025097 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 2020 |
| Title | PGC-1 alpha, Inflammation, and Oxidative Stress: An Integrative View in Metabolism |
| Authors | Rius-Perez, S; Torres-Cuevas, I; Millan, I; Ortega, AL; Perez, S; , |
| Journal | Oxidative Medicine and Cellular Longevity |
| Volume | 2020 |
| Page Numbers | 1452696 |
| Abstract | Peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1 alpha is a transcriptional coactivator described as a master regulator of mitochondrial biogenesis and function, including oxidative phosphorylation and reactive oxygen species detoxification. PGC-1 alpha is highly expressed in tissues with high energy demands, and it is clearly associated with the pathogenesis of metabolic syndrome and its principal complications including obesity, type 2 diabetes mellitus, cardiovascular disease, and hepatic steatosis. We herein review the molecular pathways regulated by PGC-1 alpha, which connect oxidative stress and mitochondrial metabolism with inflammatory response and metabolic syndrome. PGC-1 alpha regulates the expression of mitochondrial antioxidant genes, including manganese superoxide dismutase, catalase, peroxiredoxin 3 and 5, uncoupling protein 2, thioredoxin 2, and thioredoxin reductase and thus prevents oxidative injury and mitochondrial dysfunction. Dysregulation of PGC-1 alpha alters redox homeostasis in cells and exacerbates inflammatory response, which is commonly accompanied by metabolic disturbances. During inflammation, low levels of PGC-1 alpha downregulate mitochondrial antioxidant gene expression, induce oxidative stress, and promote nuclear factor kappa B activation. In metabolic syndrome, which is characterized by a chronic low grade of inflammation, PGC-1 alpha dysregulation modifies the metabolic properties of tissues by altering mitochondrial function and promoting reactive oxygen species accumulation. In conclusion, PGC-1 alpha acts as an essential node connecting metabolic regulation, redox control, and inflammatory pathways, and it is an interesting therapeutic target that may have significant benefits for a number of metabolic diseases. |
| Doi | 10.1155/2020/1452696 |
| Pmid | 32215168 |
| Wosid | WOS:000522271400005 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |