Carcinogenicity and mechanistic insights on the behavior of epoxides and epoxide-forming chemicals
Melnick, RL
HERO ID
706993
Reference Type
Journal Article
Year
2002
Language
English
PMID
| HERO ID | 706993 |
|---|---|
| In Press | No |
| Year | 2002 |
| Title | Carcinogenicity and mechanistic insights on the behavior of epoxides and epoxide-forming chemicals |
| Authors | Melnick, RL |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 982 |
| Page Numbers | 177-189 |
| Abstract | Many epoxides and their precursors are high production volume chemicals that have major uses in the polymer industry and as intermediates in the manufacture of other chemicals. Several of these chemicals were demonstrated to be carcinogenic in laboratory animal studies conducted by the Ramazzini Foundation (e.g., vinyl chloride, acrylonitrile, styrene, styrene oxide, and benzene) and by the National Toxicology Program (e.g., ethylene oxide, 1,3-butadiene, isoprene, chloroprene, acrylonitrile, glycidol, and benzene). The most common sites of tumor induction were lung, liver, harderian gland, and circulatory system in mice; Zymbal's gland and brain in rats; and mammary gland and forestomach in both species. Differences in cancer outcome among studies of epoxide chemicals may be related to differences in study design (e.g., dose, duration, and route of exposure; observation period; animal strains), as well as biological factors affecting target organ dosimetry of the DNA-reactive epoxide (toxicokinetics) and tissue response (toxicodynamics). N7-Alkylguanine, N1-alkyladenine, and cyclic etheno adducts, as well as K-ras and p53 mutations, have been detected in animals and/or workers exposed to several of these chemicals. The classifications of these chemical carcinogens by IARC and NTP are based on animal and human data and results of mechanistic studies. Reducing occupational and environmental exposures to these chemicals will certainly reduce human cancer risks. |
| Doi | 10.1111/j.1749-6632.2002.tb04932.x |
| Pmid | 12562636 |
| Wosid | WOS:000180752400011 |
| Url | https://search.proquest.com/docview/72839699?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: ISSN: |
| Is Public | Yes |
| Language Text | English |
| Keyword | vinyl chloride; vinyl halides; butadiene; styrene; ethylene oxide; glycidol; epoxides; carcinogenicity; toxicokinetic modeling; DNA adducts; etheno adducts; K-ras mutations; cancer risk; human carcinogens |
| Is Peer Review | Yes |
| Relationship(s) |
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