The role of Kupffer cell oxidant production in early ethanol-induced liver disease
Wheeler, M; Kono, H; Yin, M; Nakagami, M; Uesugi, T; Arteel, G; Gäbele, E; Rusyn, I; Yamashina, S; Froh, M; Adachi, Y; Iimuro, Y; Bradford, B; Smutney, O; Connor, H; Mason, R; Goyert, S; Peters, J; Gonzalez, F; Samulski, R; Thurman, R
HERO ID
708416
Reference Type
Journal Article
Subtype
Review
Year
2001
Language
English
PMID
| HERO ID | 708416 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 2001 |
| Title | The role of Kupffer cell oxidant production in early ethanol-induced liver disease |
| Authors | Wheeler, M; Kono, H; Yin, M; Nakagami, M; Uesugi, T; Arteel, G; Gäbele, E; Rusyn, I; Yamashina, S; Froh, M; Adachi, Y; Iimuro, Y; Bradford, B; Smutney, O; Connor, H; Mason, R; Goyert, S; Peters, J; Gonzalez, F; Samulski, R; Thurman, R |
| Journal | Free Radical Biology and Medicine |
| Volume | 31 |
| Issue | 12 |
| Page Numbers | 1544-1549 |
| Abstract | Considerable evidence for a role of Kupffer cells in alcoholic liver disease has accumulated and they have recently been shown to be a predominant source of free radicals. Several approaches including pharmacological agents, knockout mice, and viral gene transfer have been used to fill critical gaps in understanding key mechanisms by which Kupffer cell activation, oxidant formation, and cytokine production lead to liver damage and subsequent pathogenesis. This review highlights new data in support of the hypothesis that Kupffer cells play a pivotal role in hepatotoxicity due to ethanol by producing oxidants via NADPH oxidase. |
| Pmid | 11744328 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Is Qa | No |