Asbestos fibers contributing to the induction of human malignant mesothelioma
Suzuki, Y; Yuen, SR
HERO ID
709562
Reference Type
Book/Book Chapter
Year
2002
Language
English
PMID
| HERO ID | 709562 |
|---|---|
| Year | 2002 |
| Title | Asbestos fibers contributing to the induction of human malignant mesothelioma |
| Book Title | Carcinogenesis bioassays and protecting public health: Commemorating the life work of Cesare Maltoni and distinguished colleagues |
| Authors | Suzuki, Y; Yuen, SR |
| Editor | Mehlman, MA; Maltoni, C |
| Publisher Text | New York Academy of Sciences |
| City | New York, NY |
| Page Numbers | 160-176 |
| Abstract | To elucidate the features of the asbestos fibers contributing to the induction of human malignant mesothelioma, we used high-resolution analytical electron microscopy to determine the type, number, and dimensions of asbestos fibers in lung and mesothelial tissues in 168 cases of mesothelioma. Results: 1. Asbestos fibers were present in almost all of the lung and mesothelial tissues from the mesothelioma cases. 2. The most common types of asbestos fibers in lung were either an admixture of chrysotile with amphiboles, amphibole alone, and occasionally chrysotile alone. In mesothelial tissues, most asbestos fibers were chrysotile. 3. In lung, amosite fibers were greatest in number followed by chrysotile, crocidolite, tremolite/actinolite, and anthophyllite. In mesothelial tissues, chrysotile fibers were 30.3 times more common than amphiboles. 4. In some mesothelioma cases, the only asbestos fibers detected in either lung or mesothelial tissue were chrysotile fibers. 5. The average number of asbestos fibers in both lung and mesothelial tissues was two orders of magnitude greater than the number found in the general population. 6. The majority of asbestos fibers in lung and mesothelial tissues were shorter than 5 micro m in length. Conclusions: 1) Fiber analysis of both lung and mesothelial tissues must be done to determine the types of asbestos fibers associated with the induction of human malignant mesothelioma; 2) short, thin asbestos fibers should be included in the list of fiber types contributing to the induction of human malignant mesothelioma; 3) Results support the induction of human malignant mesothelioma by chrysotile. |
| Doi | 10.1111/j.1749-6632.2002.tb04931.x |
| Pmid | 12562635 |
| Wosid | WOS:000180752400010 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | NEW YORK, NEW YORK |
| Series | Annals of the New York Academy of Sciences, vol. 982(1) |
| Isbn | 9781573314060 |
| Conference Name | Conference on Carcinogenesis Bioassays and Protecting Public Health |
| Is Public | Yes |
| Language Text | English |
| Keyword | asbestos; fibers; mesothelioma; chrysotile; amphiboles |